New drugs makes it possible to teach an old mouse new tricks

New drugs makes it possible to teach an old mouse new tricksAs you know, one of the cause of memory loss with age and aging in General is the so-called free radicals - molecules that contain aggressive oxygen atoms. They contribute to the destruction of various tissues from the skin resulting in wrinkles) to areas of the brain responsible for remembering information. To bind free radicals and, consequently, slow down the aging process help a particular substance, the so-called antioxidants. These include, in particular, include vitamins a, C and E, as well as a number of enzymes, and in particular, catalase and superoxide dismutase. The latter is considered the most effective, but their molecules, and molecules of enzymes in General, very large, so not able to penetrate through the cell membrane into the cells, which doctors wanted to cure. "Besides, an excess of catalase and superoxide dismutase leads to a strong immune response: the body identifies them as foreign molecules and tries to destroy them," said the head of the group Michel Badri. Michelle Badri and his colleagues synthesized smaller molecules having the property of enzymes-antioxidants. Experiments have shown that the drugs, called EUK-189 and EUK-207, is able to penetrate into the cells. In addition, each of the molecules of new compounds able to "neutralize" several molecules containing free radicals. While the molecule most antioxidants, and including, the natural "versions" of the synthesized drugs, usually associated with only one free radical. Inspired by the unusual chemical properties of the compounds, the researchers began their laboratory tests. They implanted eight-month-old mice (in people of this age corresponds to approximately 50 years) with absorbable time capsule with new drugs, and then watched the rodents to old, murine concepts, age 11 months. To determine the severity of memory in animals, scientists have used the technology developed in the beginning of the last century, the great Russian physiologist Ivan Pavlov. Mice were placed in cages, floors, which served as the metal lattice. On the first day of the experiment through the bars for a moment an electrical current and, thus, rodents subjected to the action of electric shock. The next day, mice were placed in the same cells. They looked very tense: huddled in the corner and was always waiting, waiting for the shock. According to Badri, it was the so-called "contextual fear": "Mouse has demonstrated the ability to remember the shock," he says. - And if they do not remember, begin to move freely in the cage. Excellent memory mice was confirmed by other experiments. By studying the brains of mice, the researchers found that the subjects rodents, compared with the control group is not "treated" with drugs old mice, the brain is very slightly damaged "free radicals". Currently, the drugs recommended for clinical trials in humans. According to Badri, new drugs may be effective not only in the treatment of memory disorders, and other diseases caused by free radicals..



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